Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...

A new study shows exactly how the gene BRCA2, linked to susceptibility to breast and ovarian cancer, functions to repair damaged DNA. By studying BRCA2 at the level of single molecules, researchers at ...

The BRCA genes were first discovered for their roles in gynecological cancers, with the most deleterious mutations in BRCA1 and BRCA2 raising a woman’s lifetime risk of breast or ovarian cancer from 7 ...

ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also ...

Research has found important new ways that the BRCA1 gene functions which could help develop our understanding of the development of ovarian and breast cancers. Research led by the University of ...

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also ...

BRCA DNA-repair proteins interact with a molecular complex that is also responsible for regulating the immune system. When certain players in this pathway go awry, autoimmune disorders arise. An ...

Loss of BRCA1 function is associated with sensitivity to DNA-damaging chemotherapy and may also be associated with resistance to taxane-based chemotherapy. However, prospective clinical studies are ...

(TORONTO, Canada – July 15, 2013) – Scientists led by Drs. Mona Gauthier and Tak Mak at The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre have solved a ...