Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Immune low-response states significantly impact the effectiveness of immunotherapy in cancer treatment. These states ...

Scientists at Duke-NUS Medical School have developed two powerful computational tools that could transform how researchers ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Triglia discusses her research at the intersection of genetics, epigenetics, single-cell genomics and computational biology.

This article explores how single-cell multiomics and spatial transcriptomics are illuminating early pregnancy, uncovering ...

A technology that combines transcriptomic data and AI enables a novel approach to drug discovery based on the state of cells, how they behave and which genes they express. The Drugreflector model, ...

Researchers have created a highly detailed spatial multiomic atlas to date of glioma tumour microenvironments.